A simple and general method has been developed for one-pot three-component synthesis
of α-aminophosphonates catalyzed by several metal triflates [M(OTf)n, M = Li, Mg, Al, Cu, Ce] in the absence of solvent in good to high yields.
α-aminophosphonates - imines - diethyl phosphate - metal triflates - solvent free
- aldehydes - ketones - amines