Planta Med 2004; 70(10): 914-918
DOI: 10.1055/s-2004-832616
Original Paper
Biochemistry and Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

Phenylpropanoid NF-κB inhibitors from Bupleurum fruticosum

P. Bremner1 , S. Tang1 , H. Birkmayer1 , B. L. Fiebich2 , E. Muñoz3 , N. Marquez3 , D. Rivera4 , M. Heinrich1
  • 1The Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, London, UK
  • 2Department of Psychiatry and Psychotherapy, School of Medicine, University of Freiburg, Freiburg, Germany
  • 3Department of Cellular Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
  • 4Department of Plant Biology, Faculty of Biology, University of Murcia, Murcia, Spain
Further Information

Publication History

Received: April 26, 2004

Accepted: July 15, 2004

Publication Date:
18 October 2004 (online)

Abstract

Two phenylpropanoids from Bupleurum fruticosum (Apiaceae/Umbelliferae) were shown to inhibit the transcriptional activity induced by PMA or TNFα of an NF-κB-controlled reporter gene. Western blot experiments indicated that the phenylpropanoids did not prevent IκBα degradation, suggesting that their molecular target is at a post-IKB degradation level. Both compounds prevented cytokine (IL-1, IL-6, TNF, IL-8) release and prostaglandin E2 synthesis.

Abbreviations

AINP:anti-inflammatory natural products (EU-FP5-QLK3-2000-00463)

IκB:inhibitor of NF-κB

IL:interleukin

NF-κB:nuclear factor kappa B

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Professor Michael Heinrich

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The School of Pharmacy

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