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Synthesis 2005(3): 442-446  
DOI: 10.1055/s-2004-837299
PAPER
© Georg Thieme Verlag Stuttgart · New York

A New Approach to the Synthesis of Tazobactam Using an Organosilver Compound

Wei Liang Xu*, Yun Zheng Li, Qing Shan Zhang, He Sun Zhu
School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, P. R. China
Fax: +86(10)68913293; e-Mail: xwl3831@sina.com.cn;
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Publication History

Received 30 August 2004
Publication Date:
22 December 2004 (online)

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Abstract

Tazobactam (9) was synthesized in 8 steps from the readily accessible 6-APA. By the first use of silver triazole as reactant, the formation of the isomer 7 was avoided and a total yield of 50%, which was two to three times higher than that of reported procedures for 9, was obtained.

Key words

synthesis - 6-APA - silver triazole - β-lactamase inhibitor - isomeric

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