Synthesis 2005(4): 634-638  
DOI: 10.1055/s-2004-837307
PAPER
© Georg Thieme Verlag Stuttgart · New York

Lewis Acid Catalyzed Synthesis of N-Protected Diphenyl 1-Aminoalkyl­phosphonates

Pieter Van der Vekena, Ibrahim El Sayeda, Jurgen Joossensa, Christian V. Stevensb, Koen Augustynsa, Achiel Haemers*a
a Department of Medicinal Chemistry, , University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
Fax: +32(3)8202739; e-Mail: achiel.haemers@ua.ac.be;
b Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure links 653, 9000 Ghent, Belgium
Further Information

Publication History

Received 24 September 2004
Publication Date:
22 December 2004 (eFirst)

Abstract

Diphenyl α-aminomethylphosphonates are prepared in good yields using a Lewis acid catalyzed Birum-Oleksyszyn reaction. This approach enlarges the scope of this reaction, allowing the use of aldehydes and ketones and the use of acid-labile groups in the synthesis of mono-and disubstituted diphenyl 1-aminoalkylphosphonates.

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