Planta Med 2005; 71(1): 84-87
DOI: 10.1055/s-2005-837758
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Antitumor-Promoting Activity of Coumarins from Citrus Plants

Chihiro Ito1 , Masataka Itoigawa2 , Motoharu Ju-ichi3 , Naoyuki Sakamoto4 , Harukuni Tokuda4 , Hoyoku Nishino4 , Hiroshi Furukawa1
  • 1Faculty of Pharmacy, Meijo University, Tempaku, Nagoya, Japan
  • 2Tokai Gakuen University, Tempaku, Nagoya, Japan
  • 3Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan
  • 4Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan
Further Information

Publication History

Received: April 8, 2004

Accepted: June 4, 2004

Publication Date:
27 January 2005 (online)

Abstract

In order to identify antitumor-promoting agents, we performed primary in vitro screening of 31 coumarins isolated from 11 plants of the Citrus species (Rutaceae), examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of the 8-substituted coumarins, 8-formyl-7-hydroxycoumarin (5), osthenol (7), demethylauraptenol (8), osthenon (9) and dihydroosthenon (10), were found to significantly inhibit EBV-EA activation (IC50 : 129 - 207 mol ratio/32 pmol TPA). Osthenol (7) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

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Prof. Masataka Itoigawa

Tokai Gakuen University

2-901 Nakahira

Tempaku-ku

Nagoya, 468-8514

Japan

Phone: +81-52-801-1201

Fax: +81-52-804-1044

Email: itoigawa@tokaigakuen-c.ac.jp

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