Planta Med 2005; 71(3): 268-272
DOI: 10.1055/s-2005-837827
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

New Sesquiterpenes from Erigeron annus

Xin Li1 , Min Yang1 , Yi-Feng Han1 , Kun Gao1
  • 1College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, People’s Republic of China
Further Information

Publication History

Received: June 9, 2004

Accepted: October 12, 2004

Publication Date:
15 March 2005 (online)

Abstract

Four new and five known eudesmane-type sesquiterpenes were isolated from the aerial parts of Erigeron annus. The structures of these new compounds were elucidated by spectral means, including 2D-NMR analysis, to be 1β,4β-dihydroxyeudesman-11-ene; 1β,7α-dihydroxyeudesman-4(15)-ene; (1R,5S,6S,7S,10R)-1β, 6α-dihydroxyeudesman-4-one and 1β-D-glucopyranosyloxy-6α-hydroxyeudesman-4(15)-ene. In addition, a chemical transformation of a known compound 1β,6α-dihydroxy-eudesman-4 (15)-ene was carried out and the derivative 1β,6α-dihydroxy-4β(15)-epoxyeudesmane was obtained. Some of the compounds were evaluated for their in vitro antitumor activities.

References

Prof. Kun Gao

College of Chemistry and Chemical Engineering

State Key Laboratory of Applied Organic Chemistry

Lanzhou University

Lanzhou 730000

People’s Republic of China

Fax: +86-931-8912-582

Email: npchem@lzu.edu.cn