Planta Med 2005; 71(3): 273-274
DOI: 10.1055/s-2005-837829
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic and Antifungal Isoprenylated Xanthones and Flavonoids from Cudrania fruticosa

Yong-Hong Wang1 , Ai-Jun Hou1 , Guo-Fu Zhu2 , Dao-Feng Chen1 , Han-Dong Sun3
  • 1Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China
  • 2School of Chinese Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China
  • 3State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Academia Sinica, Kunming, P. R. China
Further Information

Publication History

Received: May 14, 2004

Accepted: October 24, 2004

Publication Date:
15 March 2005 (online)


A new isoprenylated xanthone, cudrafrutixanthone A, was isolated from the roots of Cudrania fruticosa, together with 18 known compounds. Their structures were elucidated by spectroscopic methods. Most isoprenylated xanthones exhibited cytotoxicity against HCT-116, SMMC-7721, SGC-7901, and BGC-823 cell lines with IC50 values of 1 - 5 μg/mL. Toxyloxanthone C and wighteone showed antifungal activity against Candida albicans with MICs of 25 and 12.5 μg/mL, respectively.


Dr. Ai-Jun Hou

Department of Pharmacognosy

School of Pharmacy

Fudan University

138 Yi Xue Yuan Road

Shanghai 200032

People's Republic of China

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