Planta Med 2005; 71(3): 278-280
DOI: 10.1055/s-2005-837831
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Anti-Staphylococcal and Cytotoxic Compounds from Hyptis pectinata

Mabel Fragoso-Serrano1 , Simon Gibbons2 , Rogelio Pereda-Miranda1
  • 1Departamento de Farmacia. Facultad de Química. Universidad Nacional Autónoma de México, Mexico City, Mexico
  • 2Centre for Pharmacognosy and Phytotherapy. The School of Pharmacy, University of London, UK
Further Information

Publication History

Received: July 12, 2004

Accepted: October 24, 2004

Publication Date:
15 March 2005 (online)

Abstract

Bioassay-guided fractionation of a CHCl3 extract prepared from the Mexican medicinal plant Hyptis pectinata led to the isolation of four pyrones, pectinolides A - C (1 - 3) and H (4). Activity was tracked using cultured KB cells. Multidrug-resistant strains of Staphylococcus aureus were sensitive to pectinolide H (4; KB > 20 μg/mL) in the concentration range of 32 - 64 μg/mL. The absolute stereochemistry of this new compound was established as 5S-[(4S-acetyloxy)-(1S-hydroxy)-2Z-octenyl]-2(5H)-furanone on the basis of spectral, chiroptical data and chemical correlation with pectinolide A (1). Mosher ester derivatives were used with pectinolide B (2) for confirmation of the 3′-(S) absolute stereochemistry on the side chain chiral center of pectinolides A - C.

References

Dr. Rogelio Pereda-Miranda

Departamento de Farmacia

Facultad de Química

Universidad Nacional Autónoma de México

Ciudad Universitaria

04510 DF Mexico City

Mexico

Fax: +52-55-5622-5329

Email: pereda@servidor.unam.mx