Synthesis 2005(8): 1265-1268  
DOI: 10.1055/s-2005-861875
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Alicyclic trans-β-Amino Acids from cis-β-Hydroxycycloalkane­carboxylates

Loránd Kissa, Enikő Forróa, Gábor Bernátha,b, Ferenc Fülöp*a
a Institute of Pharmaceutical Chemistry, University of Szeged, PO Box 121, 6701 Szeged, Hungary
Fax: +(36)62545705; e-Mail: fulop@pharma.szote.u-szeged.hu;
b Research Group for Heterocyclic Chemistry, Hungarian Academy of Sciences, University of Szeged, PO Box 121, 6701 Szeged, Hungary
Further Information

Publication History

Received 7 October 2004
Publication Date:
17 March 2005 (online)

Abstract

A simple and efficient method is described for the preparation of both racemic and enantiopure trans-β-amino acids with a cycloheptane or cyclooctane skeleton, starting from racemic and enantiopure ethyl cis-2-hydroxycarboxylates.