Synthesis 2005(8): 1234-1236  
DOI: 10.1055/s-2005-861877
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A Simple Synthesis of (±)-Sarkomycin [1]

Anirban Kar, Narshinha P. Argade*
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India
Fax: +91(20)25893153; e-Mail: argade@dalton.ncl.res.in ;
Further Information

Publication History

Received 6 September 2004
Publication Date:
17 March 2005 (online)

Abstract

A facile 6-step route to (±)-sarkomycin in 17% overall yield has been described via Michael addition of nitromethane to 2-hydroxymethyl-2-cyclopentenone, oxone-induced oxidative Nef reaction, and acid catalyzed dehydration.

1

NCL Communication No. 6675.

1

NCL Communication No. 6675.