Anti-Babesial Activity of Some Central Kalimantan Plant Extracts and Active Oligostilbenoids from Shorea balangeran

Abstract

Bark extracts from a total of 22 species of Central Kalimantan plants were evaluated for their anti-babesial activity against Babesia gibsoni in vitro. Of these plant species, extracts of Calophyllum tetrapterum, Garcinia rigida, Lithocarpus sp., Sandoricum emarginatum, and Shorea balangeran showed more than 90 % inhibition of the parasite growth at a test concentration of 1000 μg/mL. Activity-guided fractionation of the bark of S. balangeran (Dipterocarpaceae) led to the reisolation of oligostilbenoids, vaticanol A (1), B (2), and G (3). The structures were determined on the basis of spectral evidence. Compounds 1 and 3 showed complete inhibition on the growth of Babesia gibsoni in vitro at a concentration of 25 μg/mL, and compound 2 at concentration of 50 μg/mL.

Key words

Shorea balangeran - Dipterocarpaceae - oligostilbenoids - anti-babesial activity - Babesia gibsoni

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