Synthesis 2005(10): 1578-1580  
DOI: 10.1055/s-2005-865287
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A Facile Synthesis of 4- and 6-Aryl-Substituted Steroids by the Suzuki-Miyaura­ Cross-Coupling Reaction

Nikolai V. Lukashev*a, Gennadij V. Latysheva, Pavel A. Doneza, George A. Skryabinb, Irina P. Beletskayaa
a Chemistry Department, Moscow State Lomonosov University, Vorobievy Gory, 119992, Moscow, Russia
Fax: +7(95)4223297; e-Mail: nvluk@org.chem.msu.su;
b Ambiotech Inc., 300 E Lombard St. STE 1400 Baltimore MD 21202, USA
Further Information

Publication History

Received 25 November 2004
Publication Date:
07 April 2005 (online)

Abstract

Potential aromatase inhibitors - 4- and 6-aryl-substituted derivatives of androst-4-ene-3,17-dione and 17-hydroxyprogesterone - have been prepared by the Suzuki-Miyaura cross-coupling from their corresponding 4- and 6-bromosteroids.