Abstract
The vinylogous Mukaiyama aldol reaction is a useful method to build up complex polyketide
structures. It is successfully employed in the synthesis of the C1-C17 macrolactone
of tedanolide, a highly cytotoxic marine natural product. These studies present a
practical approach toward the total synthesis of tedanolide; it is pursued using the
appropriate C13-C23 segment that is introduced by a pivotal aldol reaction to join
both hemispheres.
Key words
aldol reactions - macrocycles - Mitsunobu - tedanolide - total synthesis
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