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Synthesis 2005(13): 2246-2252
DOI: 10.1055/s-2005-869991
DOI: 10.1055/s-2005-869991
PAPER
© Georg Thieme Verlag Stuttgart · New YorkEffective Synthesis of Enantiopure [1,2,3]Triazolo[1,5-a]- and Pyrazolo[1,5-a]-pyrrolo[2,1-c][1,4]benzodiazepines by Diastereoselective Intramolecular Azide and Nitrilimine Cycloadditions
Weitere Informationen
Received
18 February 2005
Publikationsdatum:
13. Juli 2005 (online)
Publikationsverlauf
Publikationsdatum:
13. Juli 2005 (online)
Abstract
The synthesis of new tetracyclic 1,4-benzodiazepinonic systems was performed in enantiopure form by totally diastereoselective intramolecular 1,3-dipolar cycloadditions. The absolute stereochemistry of the products was confirmed by X-ray crystallography and the enantiomeric purity was determined by using chiral HPLC.
Key words
azides - diastereoselectivity - fused-ring systems - nitrilimines - pyrrolo[2,1-c][1,4]benzodiazepines
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