Synthesis 2005(14): 2284-2286  
DOI: 10.1055/s-2005-869995
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A Facile Synthesis of Rubrolide E [1]

Anirban Kar, Narshinha P. Argade*
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India
Fax: +91(20)25893153; e-Mail: argade@dalton.ncl.res.in;
Further Information

Publication History

Received 4 March 2005
Publication Date:
13 July 2005 (eFirst)

Abstract

A simple and efficient synthesis of rubrolide E (1e) has been demonstrated via Meerwein coupling reaction of para-anisyldiazonium chloride with N-phenylmaleimide (2), regioselective reduction of para-anisylmaleic anhydride (4), Knoevenagel condensation of butyrolactone 5 with para-anisaldehyde and de­methylation pathway.

1

NCL Communication No. 6680.

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NCL Communication No. 6680.