Synthesis 2005(14): 2379-2383  
DOI: 10.1055/s-2005-870022
PAPER
© Georg Thieme Verlag Stuttgart · New York

One-Pot Synthesis and Aromatization of 1,4-Dihydropyridines in Refluxing Water

Jing-Jing Xia, Guan-Wu Wang*
Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
Fax: +86(551)3607864; e-Mail: gwang@ustc.edu.cn.;
Further Information

Publication History

Received 28 January 2005
Publication Date:
14 July 2005 (eFirst)

Abstract

A series of 1,4-dihydropyridines were synthesized in an environmentally benign method, by reacting aldehydes with acetoacetate esters or acetylacetone and ammonium acetate in refluxing water. The thus formed 1,4-dihydropyridines was subsequently oxidized in one-pot to the corresponding pyridine derivatives by either ferric chloride or potassium permanganate.

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Wang, G.-W.; Xia, J.-J.; Miao, C.-B.; Wu, X.-L., submitted.