Planta Med 2005; 71(10): 970-973
DOI: 10.1055/s-2005-871223
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Chalcones and Flavonoids from the Leaves of Muntingia calabura

Jih-Jung Chen1 , Hsinn-Hsing Lee1 , Chang-Yih Duh2 , Ih-Sheng Chen3
  • 1Graduate Institute of Pharmaceutical Technology, Tajen Institute of Technology, Pingtung, Taiwan, R.O.C.
  • 2Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C.
  • 3School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
Further Information

Publication History

Received: January 11, 2005

Accepted: February 25, 2005

Publication Date:
19 August 2005 (online)


Two new dihydrochalcones, 2′,4′-dihydroxy-3′-methoxydihydrochalcone, (-)-3′-methoxy-2′,4′,β-trihydroxydihydrochalcone, a new flavanone, (2S)-(-)-5′-hydroxy-7,3′,4′-trimethoxyflavanone, and a new flavonol derivative, muntingone, along with sixteen known compounds, were isolated from the leaves of Muntingia calabura. The structures of these new compounds were determined using spectral analyses including extensive 2D NMR data. Among the isolates, (2S)-5′-hydroxy-7,3′,4′-trimethoxyflavanone, 4′-hydroxy-7-methoxyflavanone, 2′,4′-dihydroxychalcone, and 2′,4′-dihydroxy-3′-methoxychalcone exhibited cytotoxicity (IC50 values < 4 μg/mL) against P-388 and/or HT-29 cell lines in vitro.


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Dr. J. J. Chen

Department of Pharmacy

Tajen Institute of Technology


Taiwan 907


Fax: +886-8-762-5308