Synthesis 2005(15): 2479-2481  
DOI: 10.1055/s-2005-872072
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

An Easy Two-Step Reduction of Salicylic Acids and Alcohols to 2-Methylphenols

Francesco Mazzini, Piero Salvadori*
Dipartimento di Chimica e Chimica Industriale, University of Pisa, via Risorgimento 35, Pisa 56126, Italy
Fax: +39(050)2219918260; e-Mail: lcap@dcci.unipi.it;
Further Information

Publication History

Received 26 April 2005
Publication Date:
18 July 2005 (online)

Abstract

Salicylic acids and alcohols can be reduced to 2-methylphenols by a simple two steps procedure. Reaction conditions were optimized carrying out a study on the solvent effect and the amount of the reducing agent. The improved procedure resulted particularly useful in the synthesis of deuterated building blocks of biological interest.

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