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Synthesis 2005(16): 2787-2797
DOI: 10.1055/s-2005-872096
DOI: 10.1055/s-2005-872096
PAPER
© Georg Thieme Verlag Stuttgart · New YorkSolvent-Free Synthesis of Cyanohydrin Derivatives Catalysed by Triethylamine
Weitere Informationen
Received
16 June 2005
Publikationsdatum:
22. Juli 2005 (online)
Publikationsverlauf
Publikationsdatum:
22. Juli 2005 (online)
Abstract
A very simple one-step environmentally friendly procedure for the synthesis of O-substituted cyanohydrins from aldehydes and ketones, in the absence of solvent, employing minimum amounts of the corresponding cyanides has been optimised. Aldehydes react more rapidly than ketones using triethylamine as catalyst offering in both cases almost quantitative yields of the corresponding O-trimethylsilyl, O-methoxycarbonyl, O-benzoyl and O-acetyl cyanohydrins.
Key words
addition reactions - catalysis - cyanohydrin derivatives - green chemistry - solvent-free reactions
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