Synthesis 2005(15): 2602-2605  
DOI: 10.1055/s-2005-872105
PAPER
© Georg Thieme Verlag Stuttgart · New York

Fluorination of Ketones Using Iodotoluene Difluoride

Saeko Sato, Masanori Yoshida, Shoji Hara*
Division of Molecular Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan
Fax: +81(11)7066556; e-Mail: hara@org-mc.eng.hokudai.ac.jp;
Further Information

Publication History

Received 24 December 2004
Publication Date:
29 July 2005 (eFirst)

Abstract

Fluorination of ketones was achieved by the reaction of silyl enol ethers with iodotoluene difluoride in the presence of BF3·OEt2 and a Et3N·HF complex.

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19

An equilibrium between two isomers of 7 was not observed under the reaction conditions.

21

A centrifuge tube with a screw cap made of Teflon FEP, a copolymer of TFE and hexafluoropropylene, was used.