Synthesis 2005(15): 2497-2502  
DOI: 10.1055/s-2005-872116
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 1,2,3-Triazoles by Cycloadditions of Azides with Enol Ethers

Dario R. Roque, Justin L. Neill, James W. Antoon, Erland P. Stevens*
Department of Chemistry, Davidson College, PO Box 7120, Davidson, NC 28035-7120, USA
Fax: +1(704)8942709; e-Mail: erstevens@davidson.edu;
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Publikationsverlauf

Received 24 December 2004
Publikationsdatum:
04. August 2005 (online)

Abstract

1,2,3-Triazoles were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solventless conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1,2,3-triazole products bear functionality that may be readily derivatized.