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Planta Med 2005; 71(12): 1128-1133
DOI: 10.1055/s-2005-873169
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Evaluation of Antiviral Activity of Compounds Isolated from Ranunculus sieboldii and Ranunculus sceleratus

Haibo Li1 , ChangXin Zhou1 , Yunxue Pan1 , Xiaozhong Gao1 , Xiumei Wu2 , Hua Bai2 , Linfu Zhou3 , Zhi Chen3 , Shuili Zhang1 , Shuyun Shi1 , Jiali Luo2 , Juanhua Xu1 , Liurong Chen1 , Xiaoxiang Zheng4 , Yu Zhao1
  • 1Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China
  • 2Zhejiang Hisun Naturelite Pharmaceutical R&D Co., Ltd., Hangzhou, P. R. China
  • 3Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, P. R. China
  • 4Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Sciences, Zhejiang University, Hangzhou, P. R. China
Further Information

Publication History

Received: November 25, 2004

Accepted: July 13, 2005

Publication Date:
10 November 2005 (online)

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Abstract

Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4′-O-α-rhamnopyranoside (1), apigenin 7-O-β-glucopyranosyl-4′-O-α-rhamnopyranoside (4), tricin 7-O-β-glucopyranoside (5), tricin (12), and isoscopoletin (18) possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde (19) exhibited an inhibiting activity on HSV-1 replication. It is therefore suggested that further investigations on these bioactive compounds might be needed to discover and develop new antiviral agents.

Key words

Anti-virus - Ranunculus sieboldii - Ranunculus sceleratus - Ranunculaceae - hepatitis B virus - Herpes simplex virus type-1 - flavone glycosides

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Prof. Dr. Yu Zhao

Department of Traditional Chinese Medicine and Natural Drug Research

College of Pharmaceutical Sciences

Zhejiang University

Hangzhou 310031

People’s Republic of China

Fax: +86-571-8527-0026

Email: dryuzhao@zju.edu.cn

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