Synthesis 2005(20): 3541-3548  
DOI: 10.1055/s-2005-916041
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Convenient and Efficient One-Pot Synthesis of 3-Acylisoxazoles Using Iron(III) Salts

Ken-ichi Itoha, Hiroshi Sakamakia, Noriko Nakazatob, Atsuo Horiuchib, Ernst Hornb, C. Akira Horiuchi*b
a College of Science and Technology, Nihon University, 7-24-1 Narashinodai Funabashi-shi, Chiba 274-8501, Japan
b Department of Chemistry, Rikkyo (St. Paul’s) University, 3-34-1 Nishi-Ikebukuro, Toshima-ku Tokyo 171-8501, Japan
Fax: +81(3)39852397; e-Mail: horiuchi@rikkyo.ac.jp;
Further Information

Publication History

Received 12 May 2005
Publication Date:
12 October 2005 (online)

Abstract

3-Acylisoxazoles were synthesized by the reaction of alkenes or alkynes with ketones (acetone or acetophenone), as both a reagent and the solvent, by three methods: iron(III) nitrate under reflux, iron(III) salt-nitrogen dioxide (NO2) at room temperature, and iron(III) nitrate under microwave irradiation (MW).

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The crystallographic data is deposited at the Cambridge Crystallographic Data Centre under CCDC number 262303.