Gram-Scale Synthesis of N-Aryl- and N-Aryl-N′-methylpiperazines on a Novel­, Water-Swellable, Oxethane-Linked Poly(ethylene glycol) High-Loading Resin

Abstract

A new methodology for the synthesis of N-arylpiperazines was developed using a poly(ethylene glycol)-derived solid support. The reactions proceeded in up to 60% overall yield over four steps. The scope and limitations of the method are discussed, as well as the utility of ¹³C gel-phase NMR spectroscopy for reaction monitoring.

N-arylpiperazines - solid-phase synthesis - heterocycles - cleavage - ¹³C gel-phase NMR spectroscopy

References

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