Synthesis 2006(2): 237-242  
DOI: 10.1055/s-2005-918505
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 2,3-Dihydroimidazo[1,2-b]isoquinoline-5(1H)-one and Derivatives

Mariela Bollini, Silvia E. Asís, Ana María Bruno*
Centro de Síntesis y Estudio de Nuevos Compuestos Antineoplásicos y Antiparasitarios. Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina
Fax: +54(11)49648252; e-Mail: anabruno@ffyb.uba.ar;
Further Information

Publication History

Received 17 May 2005
Publication Date:
21 December 2005 (online)

Abstract

A novel and efficient synthesis of 2,3-dihydroimidazo[1,2-b]isoquinoline-5(1H)-one by microwave irradiation is reported. Several new derivatives of 2,3-dihydroimidazo[1,2-b]isoquinoline-5(1H)-one have been synthesized by acylation using DMAP as catalyst. A kinetic study employing HPLC allowed the determination of the N- and C-acylated isomers formed.