2-Trifluoromethanesulfonyloxyindole-1-carboxylic Acid Ethyl Ester: A Practical Intermediate for the Synthesis of 2-Carbosubstituted Indoles

Abstract

Ready accessible 2-trifluoromethanesulfonyloxyindole-1-carboxylic acid ethyl ester undergoes palladium-catalyzed coupling reactions with different partners giving rise to 2-aryl, heteroaryl, vinyl, allyl, and alkynyl indoles in good to excellent yields.

indoles - palladium-catalyzed - boronic acids/esters - alkynes - heteroarylzinc chlorides

References

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