Synthesis 2006(2): 344-348  
DOI: 10.1055/s-2005-924766
PAPER
© Georg Thieme Verlag Stuttgart · New York

Water-Accelerated Synthesis of Novel Bis-2,3-dihydroquinazolin-4(1H)-one Derivatives

Mostafa Baghbanzadeha, Peyman Salehi*b, Minoo Dabiria, Gholamreza Kozehgarya
a Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, Evin, Tehran, Iran
b Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, P.O.Box 19835-389, Evin, Tehran, Iran
Fax: +98(21)22418679; e-Mail: p-salehi@cc.sbu.ac.ir;
Further Information

Publication History

Received 28 June 2005
Publication Date:
21 December 2005 (online)

Abstract

Bisdihydroquinazolinones were synthesized for the first time by a novel pseudo five-component condensation of isatoic anhydride, a primary amine, and a dialdehyde in water. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent.