Facile Synthesis of 1,1-Disubstituted Taurines

Jiaxing Huang; Da-Ming Du; Jiaxi Xu

doi:10.1055/s-2005-924767

PAPER

Facile Synthesis of 1,1-Disubstituted Taurines

Jiaxing Huang, Da-Ming Du, Jiaxi Xu*
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China
Fax: +86(10)62751708; e-Mail: jxxu@pku.edu.cn;

Abstract

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Abstract

A series of 1,1-disubstituted taurines was synthesized expeditiously from ketones via the Corey-Chaykovsky epoxidation with dimethylsulfonium methylide, episulfidation with potassium sulfocyanate, ring-opening reaction with ammonia in the presence of silver nitrate, followed by treatment with hydrogen sulfide and oxidation with performic acid.

Key words

amino acid - aminoalkanesulfonic acid - epoxide - episulfide - ketone - synthesis - taurine

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References

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