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Synthesis 2006(5): 768-770
DOI: 10.1055/s-2006-926332
DOI: 10.1055/s-2006-926332
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Towards the Synthesis of the Skeleton of Salvianolic Acid D
Further Information
Received
23 September 2005
Publication Date:
07 February 2006 (online)
Publication History
Publication Date:
07 February 2006 (online)
Abstract
A successful synthesis of the acid part of salvianolic acid D is described (eight steps from isovanillin, 22% overall yield). The benzaldehyde key intermediate was obtained in six steps in 52% overall yield and was converted into the trimethylated precursor molecule using the Knoevenagel procedure. Finally, the acid part of salvianolic acid D was obtained by the exhaustive deprotection of the methyl groups with boron tribromide.
Key words
natural polyphenols - antivirals - boron tribromide
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