Synthesis of Natural Cytotoxic Camphorataimides B and C [1]

Abstract

Recently isolated camphorataanhydride A and cytotoxic camphorataimides B and C have been synthesized using chemo­selective S_N2′ Grignard coupling reaction of p-methoxyphenyl­magnesium bromide with dimethyl bromomethylfumarate and chemoselective allylic substitution of bromide in bromoanhydride 9 with 2-propylmagnesium bromide as the key reactions. The present approach is general in nature and can be easily used to design the congeners of camphorataanhydrides/imides for structure-activity relationship studies.

Key words

dimethyl bromomethylfumarate - S_N2′ Grignard coupling reaction - functionalized maleic anhydrides - bioactive natural product synthesis - camphorataimides B and C

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NCL Communication No. 6688.

References

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NCL Communication No. 6688.