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Synthesis 2006(7): 1162-1170
DOI: 10.1055/s-2006-926390
DOI: 10.1055/s-2006-926390
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Convenient Protocol for the Alkylidenation of Lactams
Further Information
Received
22 September 2005
Publication Date:
14 March 2006 (online)
Publication History
Publication Date:
14 March 2006 (online)
Abstract
A convenient two-step preparation of alkylidenepyrrolidines is reported.
Key words
heterocycles - enamines - imides - enolates - aldol reactions
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References
A Chemical Abstracts search of compound 9a reveals 21 references to the Z-isomer and 6 to the E-isomer. However, the reports of the E-isomer only mention this compound in passing, and to the best of our knowledge full characterisation data has never been reported for this double-bond isomer. We are unaware of examples where full characterisation data of both the E- and Z-isomers of a single alkylidenepyrrolidine have been reported.