Synthesis 2006(9): 1419-1422  
DOI: 10.1055/s-2006-926421
PAPER
© Georg Thieme Verlag Stuttgart · New York

(Bromodimethyl)sulfonium Bromide Catalyzed One-Pot Synthesis of α-Aminonitriles [1]

Biswanath Das*, R. Ramu, B. Ravikanth, K. Ravinder Reddy
Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Fax: +91(40)7160512; e-Mail: biswanathdas@yahoo.com;
Further Information

Publication History

Received 7 September 2005
Publication Date:
04 April 2006 (eFirst)

Abstract

A novel, simple and efficient one-pot synthesis of α-aminonitriles has been achieved by a three-component condensation of carbonyl compounds, amines and trimethylsilyl cyanide in the presence of (bromodimethyl)sulfonium bromide as a catalyst at room temperature. The products were obtained in high yields and in short reaction times.

1

Part 67 in the series ‘Studies on novel synthetic methodologies’; IICT Communication no. 051101.

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1

Part 67 in the series ‘Studies on novel synthetic methodologies’; IICT Communication no. 051101.