Planta Med 2006; 72(7): 611-614
DOI: 10.1055/s-2006-931569
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Antimalarial Activity of Biflavonoids from Ochna integerrima

Chikara Ichino1 , Hiroaki Kiyohara1 , 2 , Noppamas Soonthornchareonnon3 , Wongsatit Chuakul3 , Aki Ishiyama4 , Hitomi Sekiguchi4 , Miyuki Namatame4 , Kazuhiko Otoguro4 , Satoshi Omura1 , Haruki Yamada1 , 2
  • 1Kitasato Institute for Life Sciences, Kitasato University, Tokyo , Japan
  • 2Oriental Medicine Research Center, The Kitasato Institute, Tokyo, Japan
  • 3Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
  • 4Research Center for Tropical Diseases, Institute for Basic Research, The Kitasato Institute, Tokyo, Japan
Further Information

Publication History

Received: December 1, 2005

Accepted: January 17, 2006

Publication Date:
29 May 2006 (online)


During the screening of antimalarial substances, the 80 % EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 μg/mL) whereas extracts from the inner barks of O. integerrima showed no antimalarial activity. Biflavanone (1), which had not been found previously from a natural plant source, was isolated as a potent antimalarial active ingredient (IC50 value: 80 ng/mL) from the extract of the outer barks. The stereoisomer of 1 ( = compound 2) was also isolated from this plant; however, its activity was significantly lower than that of 1.


Prof. Dr. Haruki Yamada

Kitasato Institute for Life Sciences

Kitasato University

5-9-1 Shirokane


Tokyo 108-8641


Phone: +81-3-3444-6164

Fax: +81-3-3445-1351