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Planta Med 2006; 72(7): 643-649
DOI: 10.1055/s-2006-931573
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

New Polyhydroxylated Triterpenes and Anti-Inflammatory Activity of Salvia hierosolymitana

A. De Felice1 , A. Bader2 , A. Leone1 , S. Sosa3 , R. Della Loggia3 , A. Tubaro3 , N. De Tommasi1
  • 1Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano, Salerno, Italy
  • 2Faculty of Pharmacy, Al-Zaytoonah Private University of Jordan, Amman, Jordan
  • 3Dipartimento dei Materiali e delle Risorse Naturali, Università di Trieste, Trieste, Italy
Further Information

Publication History

Received: June 1, 2005

Accepted: January 26, 2006

Publication Date:
29 May 2006 (online)

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Abstract

Salvia hierosolymitana (Lamiaceae) leaves were investigated for their topical anti-inflammatory properties following a bioassay-guided fractionation. The chloroform extract showed a strong inhibition of the Croton oil-induced ear oedema in mice, comparable to that of indomethacin. Phytochemical and pharmacological investigations of this extract led to the isolation of eight anti-inflammatory polyhydroxylated triterpenes of the ursane and oleanane series. Four of them are new compounds, whose structures were elucidated by NMR and mass spectroscopy as 3β,6α,23-trihydroxyurs-12,19(29)-dien-28-oic acid, 23-(trans-p-coumaroyloxy)-3β, 6α,30-trihydroxyurs-12-en-28-oic acid, 2α,3β-dihydroxyolean-28-oic acid and 24-nor-2α,3β-dihydroxyolean-4(23),12-ene.

Key words

Salvia hierosolymitana - Lamiaceae - triterpenes - anti-inflammatory activity - Croton oil ear test

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Prof. Nunziatina De Tommasi

Dipartimento di Scienze Farmaceutiche

Università di Salerno

Via Ponte Don Melillo, 1

84084 Fisciano, (SA)

Italy

Phone: +39-089-96-2647

Fax: +39-089-96-2828

Email: detommasi@unisa.it

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