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Synfacts 2006(8): 0757-0757  
DOI: 10.1055/s-2006-941934
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Cylindricine C

Contributor(s): Philip Kocienski, Thomas Snaddon
J. J. Swidorski, J. Wang, R. P. Hsung*
University of Wisconsin, Madison, USA
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Publication History

Publication Date:
21 July 2006 (online)

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Significance

Isolated from Clavelina cylindrica, Cylindricines A-K inhibit murine leukaemia and various tumor cell lines. Noteworthy in this synthesis is the efficient and elegant aza-[3+3] annulation strategy to prepare the challenging spirocyclic amine scaffold characteristic of this family.