Zirconyl Chloride: A Useful Catalyst in the Pechmann Coumarin Synthesis

Juan C. Rodríguez-Domínguez; Gilbert Kirsch

doi:10.1055/s-2006-942362

PSP

Zirconyl Chloride: A Useful Catalyst in the Pechmann Coumarin Synthesis

Juan C. Rodríguez-Domínguez^a,b, Gilbert Kirsch*^b
^a Departamento de Química, Centro de Química Farmacéutica, Calle 200 y 21, Atabey, Playa, CP: 11600, Ciudad de la Habana, Cuba
^b Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique (LIMBP), Université Paul Verlaine-Metz, 1, Boulevard Arago, 57078 Metz, France
Fax: +33(38)7315801; e-Mail: kirsch@univ-metz.fr;

Abstract

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Abstract

Coumarin derivatives were prepared using zirconyl chloride octahydrate (1%) as a Pechmann catalyst, either neat or in some cases employing small volumes of ethanol as solvent. As result of this work, coumarins were obtained in moderate to good yields.

Key words

coumarins - zirconyl chloride - Pechmann reaction

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References

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