Synthesis 2006(16): 2640-2642  
DOI: 10.1055/s-2006-942482
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

Improved Synthesis of Cationic Pyridinium-Substituted Indolizines

Bianca Furduia, Rodica Dinicab, Ioan I. Drutac, Martine Demeunynck*a
a LEDSS UMR5616 & ICMG-FR2607, Université Joseph Fourier, BP53, 38041 Grenoble cédex 9, France
Fax: +33(476)514946; e-Mail: martine.demeunynck@ujf-grenoble.fr;
b University Dunarea de Jos, Domneasca str 47, Galati 800008, Romania
c University ‘Al. I. Cuza’, Organic Chemistry Department, Blvd Carol I 11, Iassi 700506, Romania
Further Information

Publication History

Received 24 February 2006
Publication Date:
12 July 2006 (eFirst)

Abstract

This paper describes the optimization of the synthesis of pyridinium-substituted indolizines. Different conditions, solution and solid-phase synthesis were used for the key step of [3+2] cycloaddition. The best yields and shortest reaction time were obtained by microwave-assisted solid-phase synthesis.

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