One-Step Tethering of ω-Mercaptoalkyl Function to Alcohols

Moshe Nahmany; Artem Melman

doi:10.1055/s-2006-942516

PAPER

One-Step Tethering of ω-Mercaptoalkyl Function to Alcohols

Moshe Nahmany, Artem Melman*
Department of Organic Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
Fax: +972(2)6585279; e-Mail: amelman@chem.ch.huji.ac.il;

Abstract

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Abstract

A new method of attachment of ω-mercaptoalkyl function to primary, secondary, and tertiary hydroxy groups based on ω-mercaptoalkyl monomalonates is reported. The attachment process proceeds in one stage and does not require a deprotection step thus directly providing high yields of unsymmetric malonates possessing a terminal thiol functionality.

Key words

thiols - acylations - chemoselectivity - esters - self-assembly

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References

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