A new method of attachment of ω-mercaptoalkyl function to primary, secondary, and
tertiary hydroxy groups based on ω-mercaptoalkyl monomalonates is reported. The attachment
process proceeds in one stage and does not require a deprotection step thus directly
providing high yields of unsymmetric malonates possessing a terminal thiol functionality.
thiols - acylations - chemoselectivity - esters - self-assembly