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DOI: 10.1055/s-2006-947264
Hinokiresinol Inhibits IgE-induced Mouse Passive Cutaneous Anaphylaxis Reaction
Publikationsverlauf
Received: April 21, 2006
Accepted: August 14, 2006
Publikationsdatum:
18. Oktober 2006 (online)
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Abstract
The antiallergic effect of hinokiresinol isolated from the whole plant of Trapa pseudoincisa S. at. Z. was measured in vitro and in vivo. Hinokiresinol not only potently inhibited β-hexosaminidase release from RBL-2H3 cells induced by IgE, with an IC50 value of 98 μM, but also inhibited the proinflammatory cytokines IL-6, IL-4 and TNF-α in RBL-2H3 cells stimulated by IgE. Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE.
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