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DOI: 10.1055/s-2006-949803
Antiparasitic Activity of Some Xanthones and Biflavonoids and Identification of a New Biflavanoid from the Root Bark of Garcinia livingstonei
A new biflavanoid, ent-naringeninyl-(I-3,II-8)-4'-O-methylnaringenin (1), along with five known xanthones and two known biflavonoids, (+)-volkensiflavone and (+)-morelloflavone, was isolated from the root bark of Garcinia livingstonei (Clusiaceae) T. Anders., collected in Tanzania. The absolute configuration of 1 was established by CD spectroscopy. This compound showed a moderate activity against P. falciparum (IC50 6.0±1.7µM). Antitrypanosomal activity (IC50 0.87±0.23µM) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one. The dimeric xanthone garcilivin A showed a higher and non-selective antiparasitic activity and cytotoxicity (IC50 2.0±0.1µM against MRC-5 cells) than its diastereoisomer garcilivin C (IC50 52.3±5.5µM).