Planta Med 2006; 72 - P_154
DOI: 10.1055/s-2006-949954

Sesquiterpene Lactones and Flavonoids from the aerial parts of Anthemis melanolepis L

H Skaltsa 1, V Saroglou 1, Z Kypriotakis 2
  • 1Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, GR–157 71, Athens, Greece
  • 2Technological Education Institute, School of Agricultural Production, Laboratory of Taxonomy and Management of Wild Flora, Stavromenos P.O. Box 140, Heraclion-Crete, 71110, Greece

Continuing our research on the chemical constituents from the aerial parts of Greek Anthemis melanolepis L., a species belonging to the section Cota [1], we report here the isolation and identification of sesquiterpene lactones 1-6, flavonoids 7-11, p-anisic acid and protocatechic acid. The isolation was proceeded according to the Bohlmann isolation method [2]. The structures of the isolated compounds 1–10 were elucidated by spectroscopic methods, particularly high-field NMR spectroscopy. Compounds 1 and 2 namely melanolepin B and melanolepin C are two new naturally occurring of sesquiterpene lactones. Besides compounds 1 and 2, four known sesquiterpene lactones and five flavonoids were isolated, namely β-cyclopyrethrosine (3), β-hydroxy-1-desoxotamirin(4), 1α-hydroxyacetyltulirinol, 4α,5β-epoxide (5), deacetylludalbin (6), apigenin (7), 7, 4' dimethylether- apigenin (8), dihydrokaempferol (9) and 5,7,3'-trihydroxy-3,6,4'-trimethoxy-flavonol (10) and naringenin (11).

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References: 1. Davis, P. H. (1975), Flora of Turkey and the East Aegean islands, Edinburgh, Vol. 5: 174–221. 2. Bohlmann, F. et al. (1984), Phytochemistry 23: 1979–1988.