Bioassay Guided Isolation of a New C18-Polyacetylene, (+)-9(Z),17-Octadecadiene-12,14-diyne-1,11,16-triol, from Cassonia barteri

S. Papajewski; J. H. Guse; I. Klaiber; G. Roos; R. Süßmuth; B. Vogler; C. U. Walter; W. Kraus

doi:10.1055/s-2006-957492

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Planta Med 1998; 64(5): 479-481
DOI: 10.1055/s-2006-957492

Letters

Bioassay Guided Isolation of a New C₁₈-Polyacetylene, (+)-9(Z),17-Octadecadiene-12,14-diyne-1,11,16-triol, from Cassonia barteri

S. Papajewski¹ , J. H. Guse¹ , I. Klaiber¹ , G. Roos¹ , R. Süßmuth² , B. Vogler¹ , C. U. Walter¹ , W. Kraus¹

¹Institut für Chemie, Lehrstuhl für Organische Chemie, Universität Hohenheim, Stuttgart, Germany
²Institut fšr Mikrobiologie, Universität Hohenheim, Stuttgart, Germany

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Publication History

1997

1998

Publication Date:
04 January 2007 (online)

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Abstract

A novel C₁₈-polyacetylene, (+)-9(Z),17-octadecadiene-12,14-diyne-1,11,16-triol (3), has been isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves collected in Cameroon. The structure determination was achieved by NMR, mass, IR, and UV spectroscopy. The new polyenyne shows antibacterial activity against Bacillus subtilis and Pseudo-monas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata at low concentrations, and in addition it possesses haemolytic activity.

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