Phenolic and Antibacterial Constituents of Vahlia capensis

Runner R. T. Majinda; Modisa Motswaledi; Roger D. Waigh; Peter G. Waterman

doi:10.1055/s-2006-957671

Planta Medica, Table of Contents

Planta Med 1997; 63(3): 268-270
DOI: 10.1055/s-2006-957671

Letters

Phenolic and Antibacterial Constituents of Vahlia capensis

Runner R. T. Majinda¹ , Modisa Motswaledi² , Roger D. Waigh³ , Peter G. Waterman³

¹Department of Chemistry, University of Botswana, P/Bag 0022, Gaborone, Botswana
²Institute of Health Sciences, Box 985, Gaborone, Botswana
³Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow Gl 1XW.U.K.

Abstract

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Abstract

The n-butanol fraction of Vahlia capensis yielded kaempferol, quercetin, afzelin, astragalin, quercitrin, iso-quercitrin, rutin, gallic acid, chiro-inositol, dulcitol, and a novel biflavonoid, VC-15B (vahlia biflavone). The compounds were identified using ID and 2D NMR techniques and FABMS. Vahlia biflavone and gallic acid were isolated, using bioassay-guided procedure and identified as the antibacterial components. Both compounds showed activity against Gram positive Staphylococcus aureus and Bacillus subtilis. Vahlia biflavone gave MIC values of 15.3 µg/ml and 30.6 µg/ml against S. aureus and B. subtilis, respectively while gallic acid gave a value of 71.3 µg/ml for both organisms.

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