Phytochemical Reinvestigation of Xysmalobium undulatum Roots (Uzara)1

Majid Ghorbani; Macki Kaloga; Hans-Hasso Frey; Gisela Mayer; Eckhart Eich

doi:10.1055/s-2006-957697

Planta Medica, Table of Contents

Planta Med 1997; 63(4): 343-346
DOI: 10.1055/s-2006-957697

Papers

Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Phytochemical Reinvestigation of Xysmalobium undulatum Roots (Uzara)¹

Majid Ghorbani² , Macki Kaloga² , Hans-Hasso Frey³ , Gisela Mayer⁴ , Eckhart Eich²

²Institut für Pharmazie II, Pharmazeutische Biologie, Freie Universität Berlin, D-14195 Berlin, Germany
³Institut für Pharmakologie und Toxikologie des Fachbereichs Veterinärmedizin, Freie Universität Berlin, D-14195 Berlin, Germany
⁴Schering AG, Abt. IPCH Strukturanalyse, D-13353 Berlin, Germany

1 Presented in part at the International Symposium “Biology and Chemistry of Active Natural Substances”, July 17-22, 1990, Bonn, Germany, Planta Med. 56 (1990), 550

Abstract

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Abstract

Four major cardenolide glycosides of Xysmalobium undulatum (L.) R. Br. roots (Uzara) have been isolated for the first time in pure form. The structures were elucidated by spectral analyses and determined as sophorosides and their 17-epimers, respectively. Thus, the structural elucidation of uzarin and xysmalorin, the two main glycosides, has been completed. The corresponding H-17β isomers, allouzarin and alloxysmalorin, were characterized as genuine compounds.

Key words

Xysmalobium undulatum - Asclepiadaceae - cardenolide glycosides - sophorosides - Uzara - uzarin - xysmalorin - allouzarin - alloxysmalorin

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