Inhibition of Tyrosine Hydroxylase by Bulbocapnine

Yong He Zhang; Jung Soo Shin; Sang Sun Lee; So Hee Kim; Myung Koo Lee

doi:10.1055/s-2006-957702

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Planta Med 1997; 63(4): 362-363
DOI: 10.1055/s-2006-957702

Letters

Inhibition of Tyrosine Hydroxylase by Bulbocapnine

Yong He Zhang, Jung Soo Shin, Sang Sun Lee, So Hee Kim, Myung Koo Lee

College of Pharmacy, Chungbuk National University, San 48, Kaeshin-Dong, Cheongju 361-763, Korea

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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

The inhibitory effects of bulbocapnine, an aporphine isoquinoline alkaloid, on bovine adrenal tyrosine hydroxylase (TH) were investigated. Bulbocapnine had an inhibitory effect on the enzyme (43.6% inhibition at concentration of 200 µM). Bulbocapnine exhibited uncompetitive inhibition on bovine adrenal TH with a substrate L-tyrosine. The K _i value was found to be 0.20 mM.