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Planta Med 1997; 63(6): 503-507
DOI: 10.1055/s-2006-957751
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antimicrobial Activity of Polyacetylenes from Bellis perennis and their Synthetic Derivatives

Pinarosa Avato1 , Cesare Vitali1 , Piernatale Mongelli1 , Aldo Tava2
  • 1Dipartimento Farmaco-Chimico, Facoltà di Farmacia, Università, Via Orabona 4, I-70125 Bari, Italy
  • 2Istituto Sperimentale per le Colture Foraggere, V. le Piacenza 29, I-20075 Lodi, Italy
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Publication History

1996

1997

Publication Date:
04 January 2007 (online)

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Abstract

The chemical investigation of the essential oils from the aerial organs of Bellis perennis L., the common daisy, showed that polyacetylenes were one of the dominant class of compounds. The major constituents, methyl deca-4,6-diynoate and deca-4,6-diynoic acid, and their structural analogues, deca-4,6-diyne, dimethyl octa-3,5-diyne-1,8-dioate and deca-4,6-diyne-1,10-dioic acid, were synthesised and their antimicrobial activity evaluated. Only deca-4,6-diynoic acid and deca-4,6-diyne-1,10-dioic acid showed antimicrobial activity, being the two compounds mainly effective against Gram-positive and Gram-negative bacteria, respectively. Structure-activity relationships of the tested polyacetylenes are discussed.

Key words

Bellis perennis L. - Asteraceae - daisy - polyacetylenes - deca-4,6-diynoic acid - deca-4,6-diyne-1,10-dioic acid - antimicrobial activity