Antifungal Activity from Alpinia galanga and the Competition for Incorporation of Unsaturated Fatty Acids in Cell Growth

Hiroyuki Haraguchi; Yoshiharu Kuwata; Kozo Inada; Kazushi Shingu; Kazumoto Miyahara; Miyoko Nagao; Akira Yagi

doi:10.1055/s-2006-957890

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Planta Med 1996; 62(4): 308-313
DOI: 10.1055/s-2006-957890

Papers

Antifungal Activity from Alpinia galanga and the Competition for Incorporation of Unsaturated Fatty Acids in Cell Growth

Hiroyuki Haraguchi¹ , Yoshiharu Kuwata¹ , Kozo Inada¹ , Kazushi Shingu² , Kazumoto Miyahara² , Miyoko Nagao³ , Akira Yagi³

¹Faculty of Engineering, Fukuyama University, Gakuen-cho, Fukuyama 729-02, Japan
²Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573-01, Japan
³Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Gakuen-cho, Fukuyama 729-02, Japan

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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

An antimicrobial diterpene was isolated from Alpinia galanga in the screening for potentiators of phytochemical antibiotic action. The structure was elucidated by spectral data and identified as (E)-8β,17-epoxylabd-12-ene-15,16-dial (1). Diterpene 1 synergistically enhanced the antifungal activity of quercetin and chalcone against Candida albicans. Antifungal activity of 1 was reversed by unsaturated fatty acids. Protoplasts of C. albicans were lysed by 1. These results suggest that antifungal activity of 1 is due to a change of membrane permeability arising from membrane lipid alternation.

Key words

Alpinia galanga (L.) Willd. - Zingiberaceae - (E)-8β,17-epoxylabd-12-ene-15,16-dial - antifungal activity - cell membrane - unsaturated fatty acids