An Antifungal Naphthoquinone, Xanthones and Secoiridoids from Swertia calycina

Sylvian Rodriguez; Jean-Luc Wolfender; Etienne Hakizamungu; Kurt Hostettmann

doi:10.1055/s-2006-958102

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Planta Med 1995; 61(4): 362-364
DOI: 10.1055/s-2006-958102

Letters

An Antifungal Naphthoquinone, Xanthones and Secoiridoids from Swertia calycina

Sylvian Rodriguez¹ , Jean-Luc Wolfender¹ , Etienne Hakizamungu² , Kurt Hostettmann¹

¹Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, CH-1015 Lausanne, Switzerland
²Curphametra, Institut de Recherches Scientifiques et Technologiques, B.P 227, Butare, Rwanda

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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

A chemical and biological screening of 25 species of the Gentianaceae family has been undertaken. Both methanolic and dichloromethane extracts of Swertia calycina exhibited a strong antifungal activity against Cladosporium cucumerinum and Candida albicans. The compound responsible for this activity has been isolated and identified as 2-methoxy-1,4-naphthoquinone. It is the first naphthoquinone to be described in Gentianaceae species. LC-UV and LC-TSP-MS analysis of the crude extracts of Swertia calycina also allowed on-line identification of six known xanthones and secoiridoids.

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