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Planta Med 1995; 61(5): 406-408
DOI: 10.1055/s-2006-958125
Paper

© Georg Thieme Verlag Stuttgart · New York

Emodin Pharmacokinetics in Rabbits

J. W. Liang1 , S. L. Hsiu2 , P. P. Wu2 , P. D. L. Chao
  • 1Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan, Republic of China
  • 2School of Pharmacy, China Medical College, Taichung, Taiwan, Republic of China
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Publication History

1994

1995

Publication Date:
04 January 2007 (online)

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Abstract

Administration of emodin to rabbits by i.v. bolus resulted in a serum profile which could be well described by a two-compartment model. The AUC of emodin was 518 µg · min/ml, clearance was 72.3 ml/min, and elimination half life was 227 min which was much longer than that reported in a previous study. Oral administration of emodin resulted in a very low serum concentration. Protein binding of emodin was investigated by the equilibrium dialysis method. Emodin was found to be highly bound (99.6%) to serum protein.

Key words

Anthraquinone - emodin - pharmacokinetics

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