A Cytotoxic Diacetylene from Dendropanax arboreus

William N. Setzer; Todd J. Green; Kylen W. Whitaker; Debra M. Moriarity; Cherie A. Yancey; Robert O. Lawton; Robert B. Bates

doi:10.1055/s-2006-958139

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Planta Med 1995; 61(5): 470-471
DOI: 10.1055/s-2006-958139

Letter

A Cytotoxic Diacetylene from Dendropanax arboreus

William N. Setzer¹ , Todd J. Green¹ , Kylen W. Whitaker¹ , Debra M. Moriarity² , Cherie A. Yancey² , Robert O. Lawton² , Robert B. Bates³

¹Department of Chemistry, The University of Alabama in Huntsville, Huntsville, Alabama 35899, U.S.A.
²Department of Biological Sciences, The University of Alabama in Huntsville, Huntsville, Alabama 35899, U.S.A.
³Department of Chemistry, The University of Arizona, Tucson, Arizona 85721, U.S.A.

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Publication History

1994

1995

Publication Date:
04 January 2007 (online)

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Abstract

The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and identified by ¹H- and ¹³C-NMR spectroscopy as the acetylenic compound cis-1,9,16-heptadecatriene-4,6-diyne-3,8-diol.

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